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Human health is shaped by the interactions between social and ecological systems. In States of Disease, Brian King advances a social ecology of health framework to demonstrate how historical spatial formations contribute to contemporary vulnerabilities to disease and the opportunities for health justice. He examines how expanded access to antiretroviral therapy is transforming managed HIV in South Africa. And he reveals how environmental health is shifting due to global climate change and flooding variability in northern Botswana. These case studies illustrate how the political environmental context shapes the ways in which health is embodied, experienced, and managed.